WHAT IS LIPOSOME DRUG DELIVERY?

There is no doubt about the incredible importance of liposomal vitamin C in our life, as liposome drug delivery systems have used in clinical trials for a fantastic variety of therapeutics. Like they use in delivering everything from anticancer to anti-inflammatory, antifungal, and antibiotic medications as well as sophisticated vaccines and gene medicines.

Here are some questions regarding the necessary information of the liposomal delivery system.

For Liposomal Vitamin C, What Does Liposomal Delivery Mean?

The thing that makes liposomal vitamin C very distinctive from regular vitamin C is its excellent delivery system. Liposomes are tiny phospholipid bubbles comprising bilayer structure very similar to that of your cell membranes.

Liposomes turn out to be the best carriers for therapeutic molecules, highly efficient at delivering the vital nutrients directly into the cell. They are highly biocompatible and are able to hold either fat-soluble or water-soluble molecules. Liposomal supplements provide a nutritional well-organized delivery system with rapid uptake and delivery into the cells.

Liposomes are significant in helping antioxidant delivery, and because they are made from natural phospholipids. So, they are biocompatible and also non-toxic. Liposomal delivery systems are becoming increasingly famous for nutraceuticals. They give protection to these therapeutic molecules from any harm in the digestive system.

In cell culture studies, liposomes can enhance intracellular delivery 100-fold over a non-liposomal delivery.

What is Liposomal Delivery Related to Liposomal Vitamin C?

You cannot understand the liposomal vitamin C without understanding the liposomal delivery system. Generally, liposomal delivery systems fall into three categories;

Multi-Lamellar Vesicles or MLV are about 500-5000 nm (nanomolar) and comprising more than one bilayer.

Large Unilamellar Vesicles or LUV, are 200-800 nm containing a single bilayer.

Small Unilamellar Vesicles or SUV, range from 20-150 nm and consists of a long circulation half-life and excellent cellular delivery than larger particles.

Are liposomes natural?

Lipids making liposomes may be natural or synthetic, and liposome components are not exclusive of lipids, as new generation liposomes can also be prepared from polymers (sometimes called polymersomes).

Whether made of natural or synthetic lipids or polymers, liposomes are biodegradable and biocompatible, which makes them beneficial for biomedical research.

The unique characteristics of liposomes are due to their amazing capabilities to compartmentalize and even solubilize both hydrophilic and hydrophobic materials by nature. This exciting feature, combined with biocompatibility and biodegradability makes liposomes very useful as drug delivery vehicles and also very important in the case of liposomal vitamin C.

Do liposomes work?

Liposomes work very effectively. Like phospholipid, it has a great ability to make liposomes that you can employ as a drug targeting molecule. They also have a unique emulsifying property to stabilize the emulsions adequately. So, you can say the working of liposomes mainly depends upon its structure.

How to control drug delivery in liposome

Some new approaches like modifying the liposome bilayer with suitable amphiphiles to enhance the circulation time of liposomes such as stealth liposome promote their elasticity like in transferosomes or can develop covalent drug–lipid complexes for highly developed delivery of drugs.

These systems significantly improve drug delivery in traditional liposome systems. Therefore, by using advanced techniques, one can also control the delivery system in liposomal vitamin C.

How long has liposome drug delivery been around?

The liposomes have discovered in the mid-1960, and their resemblance to cell membranes presented cell biologists with an outstanding tool for the study of numerous cell membrane functions involving cell fusion, antigen presentation, and membrane pumps. However, several years later, they were considered as an efficient carrier for the pharmacologically active agents’ active delivery in the treatment of diseases.

The usage of liposomes in drug delivery and targeting has started at the end of 1970. It was a great achievement in the history of pharmaceutical fields.