USES OF 3 LIPOSOMAL VITAMIN C

Potential Uses of 3 Liposomal Vitamin C and method of functions. 2

What is Liposomal Vitamin C?. 2

Better Absorption?. 3

Components. 3

Function of Vitamin C.. 4

Anticipated Benefits (Possibly Effective). 4

1) Complications of Heart Attack and Stroke. 4

2) Skin Health. 5

Melasma. 5

UV Damage. 6

Animal Studies (Lacking Evidence). 6

3) Tropical Parasites. 6

Cancer Research. 6

Restrictions and Caveats. 7

Correlations with Conventional Tablets. 7

Side effects and Precautions. 7

1) Kidney Stones. 7

2) Breast Cancer. 7

Drug Interactions. 8

1) Amphetamines. 8

2) Copper. 8

3) Estrogens. 8

Genes Associated to Liposomal Vitamin C.. 8

Dosage and Sources. 8

References: 9

Bibliography. 9

 

POTENTIAL USES OF 3 LIPOSOMAL VITAMIN C AND METHOD OF FUNCTIONS

Liposomal vitamin C is a new formula to improve bioavailability contrasted with conventional tablets. How is it meant to function? Read continuously to know about the mechanism and initial clinical outcomes here.

 

WHAT IS LIPOSOMAL VITAMIN C?

 

Vitamin C (ascorbic corrosive) is vital for human health, even though the human body can’t produce vitamin C, we should get it from diet or supplements. Many people take vitamin C supplements to boost collagen production, immunity, antioxidants, and general wellbeing.

 

One of the issues with supplemental vitamin C is that a tiny percentage is retained into the circulatory system. With higher dosages, most vitamin C remains in the gut and is discharged in the end.

 

Liposomal vitamin C is an improved form with a similar active ingredient as traditional vitamin C supplements with an advanced delivery system.

What is Liposomal Vitamin C?

Liposomes are little round particles with an external layer made of fats like those in our cell membrane (phospholipids in the marked “bilayer layer” on the picture).

 

This bilayer protects the inside of every little circle (“inward watery compartment” in the picture). The bilayer is filled with water and vitamin C. As Suggested, this may permit liposomal vitamin C to combine with cells in the gut. So they allow the liposomal vitamin C to be absorbed rapidly and viable.

 

BETTER ABSORPTION?

 

Liposomal vitamin C is developed to ensure better bioavailability. It implies that a higher amount of the absorbed vitamin C should be taken up into the body, the circulatory system, and at last tissue. Some liposomal drugs have been seen to be absorbed higher than conventional medicines. However, this new technology isn’t without disadvantages.

 

In a study of 11 adults, the bioavailability of liposomal vitamin C was twice that of conventional tablets is less than intravenous injection.

 

COMPONENTS

 

Most of liposomal vitamin C products have 3 parts:

 

  1. Pure vitamin C (ascorbic acid)

 

  1. The liposome (phospholipids)

 

  • Distilled water

 

All of these ingredients are approved by the United States Food and Drug Administration as safe and non-poisonous. The specific formula may shift between producers. However, most contain just these ingredients. If you decide to utilize liposomal vitamin C, check for other ingredients also.

 

New liposomes are produced with other natural ingredients, such as medium-chain unsaturated fats (MCFAs). MCFAs may concede liposomal vitamin C a prolonged shelf-life.

 

Traditional vitamin C tablets and powders contain various extra ingredients that help during the tablet-production process, such as fillers (hypromellose), stabilizers, lubricants (magnesium stearate) flavors, and silica. These are assumed safe in specific amounts used in supplement production. However, numerous individuals decide to avoid them.

 

FUNCTION OF VITAMIN C

 

Liposomal vitamin C is absorbed in the gut when taken orally or through the skin whenever applied as an ointment or cream. When retained, it breaks down in cells and forms hydroxyproline. It is used by the body to produce collagen and connective tissue.

 

Vitamin C helps in cancer prevention in human cells by killing destructive oxidative compounds. It diminishes oxidative pressure, improves digestion and supplement nutrition absorption, and aids neurotransmitters’ production (synapses).

 

Vitamin C is engaged with breaking down tyrosine and carbohydrates, making folic acid, producing lipids and proteins, energy creation, immune system improvement, and fighting diseases.

 

ANTICIPATED BENEFITS (POSSIBLY EFFECTIVE)

 

The FDA has not approved liposomal vitamin C for any of the clinical uses described here due to a lack of high-quality clinical research. Further on, field examinations will be required. Consult with your physician before utilizing liposomal vitamin C in any case.

 

1) Complications of Heart Attack and Stroke

 

Stroke, respiratory failure, and different genuine health complexities can emerge when the supply of oxygen is hindered. Physicians may attempt to resuscitate the tissue with fresh blood after the initial shock and damage of a stroke or respiratory failure (reperfusion). The sudden progression of new oxygen can additionally harm the harmed tissues, named “ischemia-reperfusion injury.”

 

A bunch of clinical trials have proposed that intravenous vitamin C may moderate the harm of ischemia-reperfusion injury. Since liposomal vitamin C is consumed at a similar rate to intravenous vitamin C, it is proposed as an alternative to avoid damage while restoring the damaged tissues.

 

In one specialized study, 11 moderately aged, overweight members (with high standard oxidative stress) experienced a provocation of reperfusion injury on their arm. Liposomal vitamin C was close to as successful as the highest quality level, IV administration, in prohibiting tissue injury.

 

In another research on this sort of injury in rats, liposomes with both vitamin C and E forestalled harm in cerebrum tissue.

 

Liposomal vitamin C has less clinical evidence (contrasted with intravenous vitamin C) to back up its utilization in ischemia-reperfusion injury up until this point. Given the positive initial discoveries, further researches are probably going to be directed.

 

Try not to attempt to administer intravenous vitamin C to either yourself or another person. If you believe that you or a family member is having a heart attack or stroke, look for clinical consideration as soon as possible.

 

2) Skin Health

 

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MELASMA

 

Melasma is a typical skin infection that makes dull colors build up and form brown colored patches, commonly on the face. Vitamin C containing creams or washes is available for individuals with melasma. It is delivered utilizing a method called iontophoresis. In this method, a painless full-face mask conducts a small electrical current to help transport vitamin C over the skin.

 

In a study, a group of 35 patients, mostly female patients (just including one man) with melasma, liposomal vitamin C masks (iontophoresis), increased skin pigmentation by 73% in nearly two months. The patients are kept out of sun exposure and utilized mandelic/malic acid skincare items; hence, the particular function of the vitamin C is unclear.

 

In a study of 14 females with melasma (SB), liposomal vitamin C iontophoresis showed more safety and effectiveness. In this research, vitamin C was delivered in the form of nanosomes, which are mainly a small type of liposome.

 

Pectin coatings expand the amount of vitamin C that the skin absorbs from liposomes.

 

UV DAMAGE

Ultraviolet (UV) radiation injury is caused when dangerous, reactive oxygen species are formed in the skin tissue. Over the top UV introduction can prompt many skin conditions, including melanoma and other skin cancer growths. Because of its cancer prevention agent properties, vitamin C can diminish and forestall the harm when applied to the skin.

 

Animals exposed to harmful UV for a long time, a combination of cell antioxidants (vitamin C, vitamin A, and vitamin E) compact into small liposomes (nanosomes) protects against skin damage. This effect diminishes skin cancer growth and might be advantageous for disease prevention also.

 

Liposomal vitamin C is adequately stable and can pass the skin barrier better than traditional vitamin C. This makes antioxidant liposomes perfect for maintaining the skin from UV radiation. Liposomal cancer prevention agents (as nanosomes), including vitamin C, protects skin cells presented to UVA harm.

 

ANIMAL STUDIES (LACKING EVIDENCE)

 

3) Tropical Parasites

 

Visceral leishmaniasis (VL) is an extreme, possibly deadly tropical sickness brought by parasites. In contaminated mice, liposomes containing a mix of vitamin C and a conventional medication (antimonial) were compelling at killing the pests. The drug is expected to kill the parasite. However, Vitamin C seemed to lessen its harmful reactions.

 

CANCER RESEARCH

 

High doses of vitamin C are utilized to fight cancer in assortment with formal chemotherapy. Vitamin C lacks proof to be adopted as the sole cancer treatment, as per a meta-examination of more than 30 human preliminaries. The researchers figured that it has a decent safety profile and may improve the comfort of cancer patients.

 

Liposomal vitamin C, because of its high bioavailability, might be a suitable option in contrast to IV administration. Liposomes are less unpleasant for patients.

 

RESTRICTIONS AND CAVEATS

 

Not every individual can absorb nutrients and vitamins from food at a similar rate. An analysis of portraying benefits in specific people may not matter to other people.

 

Individual dissimilarities are challenging to define in the analysis of vitamin benefits. It’s still not easy to find a suitable vitamin and antioxidants. Most studies show that vitamin and antioxidants rich food is more effective than vitamin supplement alone. By the way, more researches are necessary to find out the distinctive outcome.

 

CORRELATIONS WITH CONVENTIONAL TABLETS

 

Vitamin C levels arrive at a certain level of impact with oral vitamin C. This indicates that after reaching a specific range, the level of Vitamin-C cannot rise further in oral tablet form. The primary advantage of liposomal vitamin C here is quicker and better abortion than traditional vitamin C tablets. The body can absorb oral liposomes up to a specific dose. Further researches are expected to figure out what the maximal portion is.

 

SIDE EFFECTS AND PRECAUTIONS

 

1) Kidney Stones

 

The dietary level of vitamin C (75 – 100 mg for each day) was not connected to kidney stones in one research. An exceptionally high dose of supplemental vitamin C (over 2 g for every day) was related to men’s kidney stones. Lower dosages of liposomal vitamin C may cause a similar sort of threat because of higher bioavailability.

 

2) Breast Cancer

 

The connection between vitamin C intake and breast cancer is dubious. Vitamin C supplement use was related to a high rate of breast cancer in postmenopausal females who previously had vitamin C rich eating habits, as per a large study (between 1995 and 2008).

 

Increased risk of breast cancer is identified with a higher intake of vitamin C. So. A few experts suggest that females should limit vitamin C admission to normal dietary levels. The NIH recommends that adult females get 75 mg of vitamin C every day, expanding to 85 mg during pregnancy and 120 mg during lactation.

 

 

DRUG INTERACTIONS

 

This isn’t considered a potential interaction with liposomal vitamin C. Consult with your physician to avoid adverse effects.

 

1) Amphetamines

 

Vitamin C reduces the amount of amphetamines (dextroamphetamine, benzphetamine, and so on) in rats. Patients who use amphetamines for ADD/ADHD and related issues should be careful in using liposomal Vitamin C.  It may reduce the impacts of their medication.

 

2) Copper

 

In the presence of copper in the blood, the effects of vitamin C are reduced. Copper alters the DNA-protective effect of vitamin C. vitamin C, as cell reinforcement, kills metal particles.

 

3) Estrogens

 

Vitamin C can promote estrogen hormone secretion (Estradiol, Estrone, Hexestrol, and so forth.). Patients who use estrogens (counting contraception pills also) must be aware of this interaction. In a study, vitamin C stimulated estradiol generation in cells. Clinical trials are missing.

 

GENES ASSOCIATED TO LIPOSOMAL VITAMIN C

 

The genes liable to retain vitamin C in the intestine (SVCT) have two specimens in healthy people. In one analysis, mice without this gene consumed considerably less vitamin C from their diet. Liposomal vitamin C may bypass this vehicle protein.

 

DOSAGE AND SOURCES

 

The National Institute of Health suggests a vitamin C quantity of 90 mg/day in grown-up men and 75mg/day in adult ladies with a furthest restriction of 2,000 mg/day. These quantities represent both dietary and supplemental vitamin C. Most liposomal vitamin C recipes contain 100 – 300 mg of vitamin C per dose.

 

While high doses of vitamin C might be required in specific issues and health conditions, most healthy people get adequate vitamin C from dietary sources (predominantly leafy foods) alone. Liposomal vitamin C, because of its high absorption rate, is more fit for treating explicit illnesses than daily supplementation.

 

The best dietary source of vitamin C is peppers, organic citrus products, and cruciferous vegetables like broccoli.

 

REFERENCES:

BIBLIOGRAPHY

Davis, J. L. (2016). Liposomal-encapsulated Ascorbic Acid: Influence on Vitamin C Bioavailability and Capacity to Protect Against Ischemia–Reperfusion Injury. Nutr Metab Insights, 9, 25. . Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915787

Hemilä, H. (n.d.). Does Vitamin C Alleviate the Symptoms of the Common Cold?–A Review of Current Evidence. Scand J Infect Dis, 26(1), 1–6. Retrieved from https://pubmed.ncbi.nlm.nih.gov/8191227

Kraft, J. C. (2014). Emerging Research and Clinical Development Trends of Liposome and Lipid Nanoparticle Drug Delivery Systems. J Pharm Sci, 103(1), 29–52. . Retrieved from https://pubmed.ncbi.nlm.nih.gov/24338748

Padayatty, S. J. (2016). Vitamin C physiology: the known and the unknown and. Oral diseases, 22(6), 463. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959991

Padayatty, S. J.-H. (2003). Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention. J Am Coll Nutr, 22(1), 18–35. Retrieved from https://pubmed.ncbi.nlm.nih.gov/12569111

Wei, L. L. (2016). Association of Vitamin C With the Risk of Age-Related Cataract: A Meta-Analysis. Acta Ophthalmol, 94(3), 170–176. Retrieved from https://pubmed.ncbi.nlm.nih.gov/25735187

Yang, S. L. (2013). Preparation and Characterization of Nanoliposomes Entrapping Medium-Chain Fatty Acids and Vitamin C by Lyophilization. Int J Mol Sci, 14(10), 19763. . Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821584

Zhou, W. L. (2014). Storage Stability and Skin Permeation of Vitamin C Liposomes Improved by Pectin Coating. Colloids Surf., B, 117, 330–7. Retrieved from https://pubmed.ncbi.nlm.nih.gov/24681045