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How to Pick the Best Liposomal Vitamin C (Plus Risks + Benefits)

How to Pick the Best Liposomal Vitamin C (Plus Risks + Benefits)

Vitamin C is of immense benefit to the human body, and there is no argument. Nevertheless, vitamin C usage makes a significant variation in how quickly the body can absorb and utilize (the "bioavailability" function of all medications). 

A novel alternative for high-dose Vitamin C is liposomal (or proliposomal) vitamin C. 

The body typically consumes from 14-30% of vitamin C consumed in the shape of medication. (Source 1) It will differ considerably in the amount due to your particular preferences for vitamin C and the form of nutrients you get. Five fresh food portions rich in C vitamins a day should have enough vitamin C, such as berries, kiwi, broccoli, and citrus. The introduction of additional vitamin C ascorbic acid as the corresponding source of vitamin C present naturally in food would help raise blood concentrations. Normal vitamin C absorption decreases by up to 50 percent over the dosage of about 200 mg. (Source 2) This can be achieved because our bodies are using some vitamin C carriers in the intestine of the sodium-dependent vitamin C (SVCT -1), which are absorbed just useful to a certain degree, and our bodies regulate via the amount of vitamin C in plasma (blood). Any extra vitamin C ingested is often excreted in the urine to keep a close eye on plasma levels. Liposomal Vitamin C is of use in this regard. 

Liposomes are microscopically dependent phospholipids comprising vitamin C. Their uptake does not rely on vitamin C carriers like SVCT-1 but the straightforward combination of the liposome with the tiny intestinal cells, ultimately leading to direct intracellular discharge of the vitamin C. 

Liposomal vitamin C has a significantly higher rate of uptake than standard vitamin C products but has its range of health benefits. This is the same method used to circumvent vitamin C carriers, which are slow due to the phospholipids used to encircle or encompass the vitamin C. The concept of liposomes and how to select the right liposome supplement and possible side effects are addressed here. 


Generally, liposomes are cell-like. Even the exterior layer of liposomes is made up of the same phospholipids as the cell membranes. Phospholipids are present in the inner and external walls of the liposome. Phosphatidylcholine is by far the most prominent way to produce a lipid bilayer. A dual coating of phospholipids (bilayer phospholipid) produces an aqueous portion (water-containing), for example, a dissolved vitamin C portion. 

As the external surfaces of liposomes mimic our cell membranes, liposomes can 'fuse' with other cells while they are in proximity and transfer the liposome contents to the cell. The practical benefit of the liposomal supply network is this.

During the 1960s, liposomes were identified. The new distribution method provides a precise means of delivering nutrients into the body without the degradation of the natural enzymes and acid contained in the digestive tract and the stomach. 

Liposomal Vitamin C

Such phospholipids are used to encapsulate the core of vitamin C.  

Liposomes are believed to combine with the cells that consume nutrient components of the gut lining called enterocytes. The bioavailability is far better than regular vitamin c supplementation since they bypass the usual vitamin C absorption pathway using slow vitamin C receptors type 1 (sodium-dependent Vitamin C receiver SCVT 1). (Source 3) 

In aspects of uptake, having to take a liposomal form of vitamin C is far more productive and efficient than conventional methods. 

Five Liposomal vitamin C advantages

The regular usage of vitamin C (ascorbic acid) gives the human body many advantages. These advantages can be increased when liposomal C is taken.


  1. Bioavailability 

The most obvious advantage is the significantly higher bioavailability of liposomal vitamin C compared with regular type. 

Bioavailable implies precisely how easily the body consumes vitamin C. When described above, the small intestine consumes more of the nutrient than a standard vitamin C replacement because of the liposomal vitamin C substitute.


A 2016 research in 11 humans showed that, relative to a non-encapsulated (non-liposomal) substitute of the same dosage, vitamin C levels improved significantly in the bloodstream in the liposome by 4 grams. (Footnote 4)

Bioavailability of liposomal vitamin C is only exceeded by intravenous vitamin C. lV vitamin C is 100% bioavailable but invasive by nature. It needs a needle injection, a specially trained facility, and a period of 1 to 3 hours for regular ingestion.


The most common application of high-dose IV vitamin C is in combination with cancer therapy and the effect on oxidation due to hefty IV doses of vitamin C. The high-dose IV vitamin C antioxidant activity varies significantly from that of the small dose of antioxidant vitamin C.


  1. Development of the heart and brain

According to a 2004 study in the American Journal of Clinical Nutrition, vitamin C intakes (through diet or supplements) will reduce the rate of heart disease and stroke by about 25 percent. (Spring 5)


Every kind of treatment of vitamin C increases all endothelial and ejection functions. [Source 6] 

The endothelial activity includes blood vessel contracting and relaxing, blood clotting development, immunity, and platelet adhesion. As the heart contracts with each beat, the ejection fraction describes the "unit amount of blood expelled (or ejected) from the ventricles." 

Such combined findings show that vitamin C may serve a significant role in the prevention and recovery of cardiovascular diseases. 

The tissue harmed by the loss of oxygen has to be treated following a stroke or heart attack. The restoration of blood flow tends to lead to tissue loss called reperfusion injury, preceded by increased production of free radicals, due to the reoxygenation of originally oxygen-reduced cells. (From Source 7) 

Vitamin C is an effective antioxidant when administered intravenously that counters and neutralizes free radicals that cause reperfusion oxidative stress. (Paragraph 8) 

In an experimental sample, liposomal vitamin C avoided reperfusion damage to the brain tissue before reduced blood flow. (Spring 9) 

Although IV enriched vitamin C blood is far better than liposomal vitamin C, one research has shown that liposomal vitamin C was just as successful as IV vitamin C to reduce reperfusion tissue injury. The experiment was carried out in 11 people who were partially obstructed by tourniquet's blood circulation in their bodies. 

  1. Cancer

Intravenous vitamin C can be used with conventional chemotherapy at more significant concentrations to combat cancer. It may not cure cancer by itself but can undoubtedly enhance the quality of life, vitality, and attitude for many patients with cancer. 

IV vitamin C may even stimulate cancer reversion on a case-by-case premise. In the 2014 evaluation, IV vitamin C with chemotherapy is reported on many withdrawal documents. (Source 10) 

Even so, IV vitamin C should not be used to cause regression or to cure cancer by itself, since these instances are at best distant. That being said, vitamin C can be a better alternative to conventional therapy for cancer


In human beings with cancer, liposomal vitamin C was not explicitly tested. Nevertheless, many IV vitamin C cancer patients also use high-dose liposomal vitamin C in IV therapies. It is not unusual for blood levels to dip below usual in the days immediately following injection after a high dose of IV vitamin C (estimated concentrations). Thus, it is strongly recommended that oral vitamin C intakes during IV vitamin C infusions be improved, mainly to avoid low plasma rebound amounts of vitamin C


  1. Manufacture of collagen

However, our development of natural collagen is reduced by around age 25. Collagen is the most abundant protein in our body. Vitamin C is a cofactor of collagen-producing proteins, which ensures that collagen prevails in the working and protecting the bones, blood vessels, and limbs. (Source 11). If quantities of vitamin C are small, such as stresses or illness and chronic disorders ( e.g., asthma, autoimmune conditions that cause elevated free radicals and oxidative stress), less is required for collagen development. Since collagen is the structural protein that maintains us together, poorer articulations, tendons, blood vessels, and connective tissue can be reflected. Wrinkles occur on the sagging skin due to weak collagen. 

  1. Oxidative Stress

Generally, with any single being, a certain level of oxidative stress exists. As reported in a 2006 evaluation: 

"There is increasing evidence connecting oxidative stress with a variety of pathological conditions including cancer, cardiovascular diseases, chronic inflammatory disease, post-ischaemic organ injury, diabetes mellitus, xenobiotic/drug toxicity, and rheumatoid arthritis." ( Source 12 )


Vitamin C is an active antioxidant present in substantial numbers in the body.


Does liposomal vitamin C work?

Liposomal vitamin C has been studied extensively.


A concern concerning liposomal supplementation is most commonly asked: is liposomal vitamin C a "hoax?."


Real liposomal or pro-liposomal foods are not harmful and can significantly improve the body's absorption of nutrients. Liposomal supplements appear to be more costly than traditional vitamin C due to the comprehensive infrastructure and technologies needed for processing but can provide better absorption. However, there is a great deal of difference between product lines, and just a little bit of homework and understanding goes a long way.


How do you know the "real" and efficient liposomal vitamin C goods?


Sadly, the word "liposome" is not clearly described compared to the phrase "liposome." This lack of a "liposomal" concept is used by several brands.


A spherical structure made of a phospholipid shell covered by water is called a "liposome." A significant component, such as vitamin C or glutathione, is usually stored in water amid a "liposome."


"Liposome" implies "liposomal," but on the other side — both words are not the same, although they sound identical. The word liposomal implies only "fat-containing" and is (quite often) used broadly. Foods that contain only fat (lipid) and vitamin C may often be considered "liposomal" combined.


A "phospholipid" is the conventional liposome shaped liposome. The most prevalent phospholipid phosphatidylcholine is the primary cell wall key component, as well as the vital part in the exterior liposome layer. Even so, the lipid form used by some supplements is not a phospholipid and can be merely a non-effective fatty acid.


Fatty acid goods can be called "liposomal" vitamin C, which can never contribute to formed liposomes even if subjected to water since it is linked with fatty acid through covalence.


An ester of vitamin C is a good illustration of a vitamin C-linked fatty acid product. Esters such as ascorbyl palmitate are typically known as lipid "soluble" vitamin C, which may never contribute to liposome development.


Ascorbyl palmitate is not present in the wild. It is formed synthetically by the chemically related vitamin C ( ascorbic acid) of palmitate (an ester). Ascorbyl palmitate is an antioxidant used commonly as food, medicines, and cosmetics for longer shelf life.


Vitamin C esters, such as ascorbyl palmitate, can be easily digested by the small intestine enzymes that instantly break the connection, producing only pure vitamin C. When the vitamin C is broken, the ester forms plain vitamin C and there is no better uptake than the conventional vitamin C supplement. (15th source, 16th source). The bioavailability of ascorbic acid alone is practically similar. (Source 18)


Based on the products themselves, the esters used may also have a detrimental effect.


Also, ascorbyl palmitate is a toxic agent for UV exposed skin cells as per one report, as opposed to ascorbic acid. (Source 17)


The ascorbyl palmitate formula, linking oleate to ascorbic acid, is very identical to ascorbyl oleate. Too little is understood about cetyl ascorbate, although another type of vitamin C is esterified.


The bottom line is: these "lipid soluble" sources of Vitamin C are easily digested before ingestion, introducing pure vitamin C into the small intestine. It ultimately contributes to a mistake by clients to pay top dollars for goods that are not that different from a usual vitamin C pill or powder, but have to since it has the name liposomal attached to it. Due to the cost of these types, they usually have a lower cost but still have a considerable amount of vitamin C per serving, such as 1200-1800 mg. So to address the issue, then, Liposomal vitamin C is not a 'hoax,' but all liposomal vitamin C items are not entirely of comparable value.


How to find the right intake of liposomal vitamin C


Multiple companies offer medications with liposomal vitamin C. What is the perfect supplement for liposomal vitamin C?


Two primary forms of liposome supplements are correlated with the development of 'liposomes.' The first is a liposome vitamin C, and the other is a proliposome. A vitamin C pro-liposome produces phospholipids that contribute to the liposome formation at a body 's temperature, in the presence of water.


If a substance is a shaped liposome, then it is the easiest way to determine whether the contents contain water. You typically work with formed liposomes because there is water in the ingredients. If not, a pro-liposome is stared at. Make sure both comprise phospholipids such as lecithin-derived phosphatidylcholine.


A proliposome can be a liposome when introduced to water, causing phospholipids automatically to accumulate into a bi-layer, as mentioned before, by natural hydrophobic influences.




Vitamin C is encircled in the shape of a proliposomal powder (conjugated) by a phospholipid layer and other fats in a design methodology, which can vary considerably in efficacy. This proper lipid-binding mechanism is carried out with vitamin C is essential. When lipids and vitamin C are only blended (not bound), the development of liposomes within vitamin C is at best intermittent, because vitamin C will spread away from the lipids independently.


Proliposomal fluid contains fats and lipids, and vitamin C. Such lipids develop liposomes around the main ingredient, based on proprietary processing methods, as they are subjected to water and the appropriate temperature levels, just like the intestinal environment.


Then the freshly developed liposomes will be ingested into bloodstream circulation via the intestinal walls, transmitted to and administered by the liver.


Reiterating: phospholipids, phosphatidylcholine, and lecithin, as fatty agents, are used to build liposomes with all the liposome compositions (constructed liposomes and pro-liposomes).


Sadly, much of the "liposomal" vitamin C products can't keep the fat and vitamin C intact once introduced to small intestine liquid.


Ensure the vitamin C is excellent. Non-GMO would be a reasonable liposomal vitamin C source, and phospholipids from sunflower lecithin should likely be used.


Some consumers also claim that they want to realize vitamin C's from non-Chinese origins, but that is a matter of personal taste.


If this is crucial for you, look for Quali-C vitamin C from non-GMO European corn produced in Scotland.


A liposomal vitamin C, which also provides a promise of fulfillment with a complete reimbursement, is a significant advantage.


In conclusion: stop cliches and buy a high-quality liposome replacement by the steps outlined:


  • Use a well-formed liposomal diet that provides vitamin C and phospholipids such as phosphatidylcholine. Resist vitamin C esters, such as ascorbyl, oleate, or cetyl ascorbate. These may have little to no benefit over standard vitamin C.
  • Search for the vitamin C supply. While China is the most widely known brand name for vitamin C, Quali-C in Scotland is a product of vitamin C produced from European non-GMOs.
  • Make sure that the food does not include GMO, corn, gluten, and dairy.


Liposomal vitamin C intake


The National Health Institute suggests that males and females never consume more than 2000 milligrams of vitamin C supplementation every day.


A higher dosage could be needed for specific health conditions. For a fact, the Linus Pauling Center suggests a 2 000 milligram a day dosage, which is very healthy and can render certain people to improve absorption likely. Older people and smokers, who also have an enhanced necessity vitamin C, may gain most from this massive dose.


Usually, the first safety dose of vitamin C will be 1000-2000 mg/day. Some of the various health benefits are:


  • Immunity
  • Wellness of the brain
  • Manufacture of collagen
  • Cardiovascular safety mechanisms
  • Producing energy
  • The enhanced role of antioxidants

The defense against the harm done by oxidative reperfusion of the post-heart attack or stroke is given of 4,000 milligrams of liposomal vitamin C.


Although the outcome is very impressive, I recommend starting at a regular quota of approximately 2,000 milligrams unless you are advised by a health practitioner to take more or raise the oxidative stress levels from chronic disease or acute infection mean additional doses.


Health risks of Liposomal Vitamin C:


Although a high vitamin C dose may not be "toxic," technically, it may lead to adverse effects like nausea or diarrhea.


Interactions between Drugs

Vitamin C comes into contact with some nutrients or drugs.

Medicines treating ADD and ADHD include amphetamines. Vitamin C may disrupt the effect of restricting amphetamine-based drugs, even though effects have not been replicated in human beings.




  • Liposomal vitamin C is a radical approach to vitamin C incorporation.
  • Liposomes use a bilayer of phospholipids formed around water. Interior nutrients are shielded from degradation that may arise through regular absorption by the external shell.
  • Liposomal vitamin C synthesis is slightly higher than the average intake of vitamin C.
  • Liposomal vitamin C advantages involve enhanced bioavailability, cardiovascular assistance, skin protection, strengthened collagen quality, and decreased body-wide oxidative stress.
  • While certain products are classified as liposomal, some do not necessarily improve the bioavailability of vitamin C esters (ascorbyl, ascorbyl, and cetyl ascorbate) and do not contribute to a liposome.
  • The daily vitamin C doses vary from 200-1,000 mg/day. To most people, we prescribe 2000 mg a day.

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